ABSTRACT
BACKGROUND: Schizophrenia has been associated with a plethora of metabolic changes in the brain that vary with duration and type of psychoses. Additionally, it has been observed that antipsychotics can further alter cerebral glucose metabolism. These changes resulting from antipsychotics have been postulated to be reflective of the duration and mechanism of action of the medication. AIMS: We aimed to examine the influence of antipsychotics on brain metabolism in individuals with schizophrenia in a naturalistic setting. SETTINGS AND DESIGN: A cross-sectional study was carried out by the psychiatry department of a tertiary care hospital in collaboration with the Radiation Medicine Centre. MATERIALS AND METHODS: Eighteen male patients with schizophrenia in different phases of treatment underwent an 18F-deoxyglucose positron emission tomography scan in a resting state 12 hours after the last dose of antipsychotic. Statistical Analysis: The types and duration of treatment were then compared with the regional glucose uptake in 14 predetermined regions of interest. The relative Uptake Values were further compared using SPSS 11.0. RESULTS: An immediate increase followed by a decrease in cortical uptake was noted while the basal ganglia uptake remained high, albeit with a decreasing trend. Typical antipsychotics were associated with lower frontal cortical and higher basal ganglia and cerebellar uptake as compared to atypical antipsychotics. CONCLUSION: The differential influence of the type and duration of antipsychotic on glucose uptake suggests a possible trend towards long-term side effects with typical medications that were not noted on clinical examination. This however needs to be confirmed with larger, controlled studies.
Subject(s)
Adult , Antipsychotic Agents/pharmacology , Brain/drug effects , Cross-Sectional Studies , Fluorodeoxyglucose F18/diagnosis , Humans , Male , Pilot Projects , Positron-Emission Tomography , Radiopharmaceuticals/diagnosis , Schizophrenia/drug therapyABSTRACT
Acquired immunodeficiency syndrome, has become a serious global health problem with an enormous biomedical impact and diverse psychological and clinical manifestation. A study was conducted wherein seropositive HIV patients admitted in a medical ward were assessed for demographic profile, presenting physical illness, mode of contacting the infection, psychiatric morbidity and associated psychosocial factors. The results revealed male preponderance and heterosexual unprotected exposure as the common mode of contacting the illness. It was observed that majority of the patients presented with tuberculosis. Psychiatric assessment revealed a high rate of depressive and anxiety syndromes. Thus it was concluded that the HIV-infected population has a higher prevalence of psychiatric disorders as compared to the general population. The reason for this includes psychological, biological and social factors.